Researching novel microfabricated devices for the quantitative imaging of living organisms.



SRK. Vedula, G. Peyret, I. Cheddadi, T. Chen, A. Brugués, H. Hirata, H. Lopez-Menendez, Y. Toyama, L. Almeida, X. Trepat, C.T. Lim* & B. Ladoux*, Mechanics of epithelial closure over non-adherent environments, Nature Communications, 6, 6111 (2015).

D. Aubry, M. Gupta, B. Ladoux, R. Allena, Mechanical link between durotaxis, cell polarity and anisotropy during cell migration, Physical Biology, 12(2):026008 (2015)

H. Hirata, M. Gupta, SRK. Vedula, C.T. Lim, B. Ladoux and M. Sokabe, Actomyosin bundles serve as a tension sensor and a platform for ERK activation, EMBO Reports 16, 250-257 (2015).

A. Ravasio, S. Vaishnavi, B. Ladoux, V. Viasnoff, High resolution imaging of cellular processes across textured surfaces using an indexed matched elastomer, Acta Biomaterialia, 14, 53-60 (2015).

M. Gupta, L. Kocgozlu, B. Sarangi, F. Margadant, M. Ashraf & B. Ladoux, Micropillar substrates: a tool for studying cell mechanobiology, Methods in Cell Biology, 125, 289-308 (2015).

T.B. Saw, S. Jain, B. Ladoux and C.T. Lim Mechanobiology of Collective Cell Migration, Cellular and Molecular Bioengineering (2015).


A. Brugués, E. Anon, V. Conte, J. H. Veldhuis, M. Gupta, J. Colombelli, J. Muñoz, G. W. Brodland, B. Ladoux*, X. Trepat* Forces driving epithelial wound healing, Nature Physics 10, 683–690 (2014).

M. Yao , W. Qiu , R. Liu , A. Efremov , P. Cong , R. Seddiki , M. Payre , C. T. Lim , B. Ladoux , R-M. Mège and J. Yan, Force-dependent conformational switch of α-catenin controls vinculin binding, Nature Communications 5, 4525 (2014).

H. van Hoorn, R. Harkes, E. M. Spiesz, C. Storm, D. van Noort, B. Ladoux and T. Schmidt, The nanoscale architecture of force-bearing focal adhesions, Nano Letters 14(8):4257-62.

M. Reffay, M.-C. Parrini, O. Cochet, B. Ladoux, A. Buguin, S. Coscoy, F. Amblard, J. Camonis, P. Silberzan, Collective migration driven by leader cells : an interplay between RhoA and forces, Nature Cell Biology 16, 217-223 (2014).

C. Plestant, P.-O. Strale, R. Seddiki, E. Nguyen, B. Ladoux and R.-M. Mège, N-cadherin engagement limits the recruitment of microtubules at cell-cell contacts through organization of acto-myosin, Journal of Cell Science (2014).

SRK. Vedula, H. Hirata, MH. Nai, A. Brugues, Y. Toyama, X. Trepat, C.T. Lim* and B. Ladoux*, Epithelial bridges maintain tissue integrity during collective cell migration, Nature Materials, 13, 87-96 (2014).

SRK Vedula, A. Ravasio, E. Anon, T. Chen, G. Peyret, M. Ashraf and B. Ladoux, Microfabricated environments to study collective cell behaviors, Methods in Cell Biology (Book series) 120, 235-252 (2014).



SRK. Vedula*, A. Ravasio, C.T. Lim and B. Ladoux* Collective cell migration: a mechanistic perspective, Physiology 28, 370-379 (2013).

K. Doxzen, SRK Vedula, Man Chun Leong, H. Hirata, Nir Gov, A. J Kabla, B. Ladoux* and C. T. Lim*, Guidance of collective cell migration by substrate geometry.Integrative Biology, 5, 1026-1035 (2013).

Y. Huang, N.-T. Nguyen, K. Seng Lok, P. Peng Foo Lee, M. Su, M. Wu, L. Kocgozlu, B. Ladoux. Multi-array cell stretching platform for high magnification real-time imaging, Nanomedecine 8, 543-53 (2013).

E.A. Booth-Gauthier, V. Du, M. Ghibaudo, A. Rape, K.N. Dahl & B. Ladoux, E.A. Booth-Gauthier, V. Du, M. Ghibaudo, A. Rape, K.N. Dahl & B. Ladoux. Hutchinson-Gilford Progeria Syndrome alters nuclear shape and reduces cell motility in 3D model substrates, Integrative Biology 5, 569-577 (2013).

MC. Leong, SRK. Vedula, CT. Lim & B. Ladoux. Geometrical constraints and physical crowding direct collective migration of fibroblasts. Communicative and Integrative Biology 6(2), e23197 (2013).

Thomas WA, Boscher C, Chu YS, Cuvelier D, Martinez-Rico C, Seddiki R, Heysch J, Ladoux B, Thiery JP, Mege RM, Dufour S. α-catenin and vinculin cooperate to promote high E-cadherin-based adhesion strength, J. Biol. Chem. 288, 4957–4969 (2013).



B. Ladoux and A. Nicolas. Physically based principles of cell adhesion mechanosensitivity in tissues. Rep. Prog. Phys. 75 (2012).

SRK. Vedula, MC. Leong, T. Lei Lai, P. Hersen, A. J. Kabla, CT. Lim* & B. Ladoux* , Emerging modes of collective cell migration induced by mechanical constraints. PNAS (2012). * Corresponding authors. Highlighted by Faculty of 1000.

A. Jasaitis, M. Estevez, J. Heysch, B. Ladoux, S. Dufour, Cadherin-dependent stimulation of traction force at focal adhesions via Src and PI3K signaling pathways. Biophysical Journal 103, 175-184 (2012).

E. Anon, X. Serra-Picamal, P. Hersen, N. C. Gauthier, M. P. Sheetz, X. Trepat & B. Ladoux, Cell crawling mediates collective cell migration to close undamaged epithelial gaps. Proc Natl Acad Sci U S A. 109, 10891-6 (2012).

F. Lebois, P. Sauvage, C. Py, O. Cardoso , B. Ladoux , P. Hersen & J-M. Di Meglio Locomotion control of Caenorhabditis elegans through confinement, Biophysical Journal 102, 2791-2798 (2012).

Trichet L., Le Digabel J., Hawkins R.J., Vedula S.R., Gupta M., Ribrault C., Hersen P., Voituriez R. & Ladoux B., Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness, Proc Natl Acad Sci U S A. 109, 6933-6938 (2012). Highlighted by Faculty of 1000.

Evenou F., Di Meglio J.M., Ladoux B., Hersen P. Micro-patterned porous substrates for cell-based assays. Lab on a Chip. 12(9):1717-22, 2012.

Biais N., Higashi D., So M., Ladoux B. Techniques to measure pilus retraction forces. Methods Mol Biol. 2012;799:197-216.


Ladoux B., Cells "feel" their environment also, BIOFUTUR, 326, 47-49 (2011).

J. Le Digabel, N. Biais, J. Fresnais, J.-F. Berret, P. Hersen & B. Ladoux. Magnetic micropillars as a tool to govern substrate deformations. Lab on a Chip, 11, 2630-2636 (2011).

S. C. Wuang, B. Ladoux & C. T. Lim. Probing the chemo-mechanotransduction effects of an anti-cancer drug emodin on breast cancer cells. Cellular and Molecular Bioengineering, 4, 466-475 (2011).

Hersen P. & Ladoux B. Biophysics: Push it, Pull it, Nature, 470, 340-1 (2011).

X. Manière, F. Lebois, I. Matic, B. Ladoux, J.-M. Di Meglio & P. Hersen. Running Worms: C. elegans self-sorting by electrotaxis. PLoS One. 6(2):e16637 (2011).

M. Ghibaudo, J.-M. Di Meglio, P. Hersen & B. Ladoux. Mechanics of cell spreading within 3D-micropatterned environments. Lab on a Chip, 11, 805-812 (2011). (Front Cover)


J. le Digabel, M. Ghibaudo, L. Trichet, A. Richert & B. Ladoux. Microfabricated substrates as a tool to study cellular mechanotransduction. Medical & Biological Engineering & Computing, 48, 965-976 (2010).

A. Saez, E. Anon, M. Ghibaudo, O. du Roure, J.-M. di Meglio, P. Hersen, A. Buguin, P. Silberzan & B. Ladoux. Traction forces exerted by epithelial cell sheets. Journal of Physics-Condensed Matter, 22, 194119 (2010).

L. Petitjean, M. Reffay, E. Grasland-Mongrain, M. Poujade, B. Ladoux, A. Buguin & P. Silberzan. Velocity fields in a collectively migrating epithelium. Biophysical Journal, 98, 1790-1800 (2010).

Y. Cai, O. Rossier, N. Gauthier, N. Biais, L. W. Miller, M. Fardin, B. Ladoux, V. W. Cornish & M. P. Sheetz. Cytoskeletal coherence depends on myosin IIA contractility. Journal of Cell Science 123, 413-423 (2010).

B. Ladoux, E. Anon, M. Lambert, A. Rabodzey, P. Hersen, A. Buguin, P. Silberzan & R-M. Mège. Strength dependence of cadherins mediated adhesions. Biophysical Journal 98, 534-542 (2010). Highlighted by Faculty of 1000.

K. N. Dahl, E. A. Booth-Gauthier & B. Ladoux. In the middle of it all: mutual mechanical regulation between the nucleus and the cytoskeleton. Journal of Biomechanics 43, 2-8 (2010).


B. Ladoux, Cells guided on their journey, Nature Physics, 5, 377-378 (2009).

M. Ghibaudo, L. Trichet, J. Le Digabel A. Richert, P. Hersen & B. Ladoux, Substrate topography induces a cross-over from 2D to 3D behavior in fibroblast migration. Biophysical Journal, 97, 357-368 (2009).


M. Ghibaudo, A. Saez, L. Trichet, A. Xayaphoummine, J. Browaeys, A. Buguin, P. Silberzan & B. Ladoux. Traction forces and rigidity sensing regulate cell functions. Soft Matter, 4, 1836-1843 (2008).

A. Rabodzey, A. Pilar, F. W. Luscinskas & B. Ladoux. Mechanical forces induced by the transendothelial migration of human neutrophils. Biophysical Journal, 95, 1428-1438 (2008).

N. Biais, B. Ladoux, D. Higashi, M. So & M. P. Sheetz Cooperative retraction of bundled type IV pili enables nanonewton force generation. PLoS Biology, 6(4), e87 (2008).


M. Poujade, E. Grasland-Mongrain, A. Hertzog, J. Jouanneau, P. Chavrier, B. Ladoux, A. Buguin & P. Silberzan Collective migration of a epithelial monolayer in response to a model wound. Proc Natl Acad Sci U S A 104, 15988-93 (2007).

A. Saez, M. Ghibaudo, A. Buguin, P. Silberzan & B. Ladoux Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates. Proc Natl Acad Sci U S A., 104: 8281-6 (2007).

E. Verneuil, B. Ladoux, A. Buguin, P. Silberzan Adhesion on microstructured surfaces. The Journal of Adhesion 83:449–472 (2007).


A. Ganz, M. Lambert, A. Saez, P. Silberzan, A. Buguin, RM. Mège & B. Ladoux Traction forces exerted through N-cadherin contacts. Biology of the Cell, 98 :721-30 (2006). (Cover)

Y. Cai, N. Biais, G. Giannone, M. Tanase, G. Jiang, J. Hofman, C. Wiggins, P. Silberzan, A. Buguin, B. Ladoux & M.P. Sheetz Non-muscle myosin IIA-dependent force inhibits cell spreading and drives F-actin flow. Biophys. J., 91: 3907-20 (2006).

A. Buguin, MH. Li, P. Silberzan, B. Ladoux & P. Keller Micro-muscles: When artificial muscles made of nematic liquid crystal elastomers meet soft lithography. J. Am. Chem. Soc. 128, 1088-9 (2006).


A. Saez, A. Buguin, P. Silberzan & B. Ladoux. Is the mechanical activity of epithelial cells controlled by deformations or forces? Biophys J. 89 L52-L54 (2005).

O. du Roure, A. Saez, A. Buguin, R.H. Austin, P. Chavrier, P. Silberzan & B. Ladoux Force mapping in epithelial cell migration. Proc. Nat. Acad. Sci. USA, 102 2390-6 (2005) .


O. du Roure, C. Dequidt, A. Richert, R.H. Austin, A. Buguin, P. Chavrier, P. Silberzan & B. Ladoux. Microfabricated arrays of elastomeric posts to study cellular mechanics. Proc. of S.P.I.E., 5345 26 (2004).


B. Ladoux, J-P. Quivy, P.S. Doyle, G. Almouzni & J-L. Viovy Direct Imaging of Single-Molecule and Micromanipulation : From Dynamics of a Single DNA Chain to the study of DNA-Protein Interactions. Science Progress, 84, 267 (2001).


B. Ladoux, J-P. Quivy, P. S. Doyle, O. du Rourre, G. Almouzni, & J-L. Viovy Fast Kinetics of Chromatin Assembly Revealed by Single-Molecule Video Microscopy and Scanning Force Microscopy. Proc. Nat. Ac. Science, 97, 14251-56 (2000).

B. Ladoux & P. S. Doyle Streching Tethered DNA Chains in Shear Flow. Europhys. Letters, 52, 511 (2000).

P. S. Doyle, B. Ladoux & J-L Viovy Dynamics of a Tethered DNA Molecule in Shear Flow. Phys. Rev. Lett., 84, 4769 (2000).


B. Ladoux, H. Isambert, J-F. Léger & J-L. Viovy New Rectifying Electrohydrodynamic Instability at the Boundary of Charged Gels in Alternating Electric Fields. Phys. Rev. Lett., 81, 3793 (1998).